Varicella-zoster virus is one of the most common viruses encountered by humans.Varicella-zoster virus is usually transmitted by airborne routes (dropletspread) with initial replication in the oropharynx (Figure 68-6). In the susceptible or seronegativeindividual, replication of virus in the oropharynx leads to primary viremia,with subsequent development of a vesicular rash. The replication ofvaricella-zoster virus in vitro is similar to that for herpes simplex virus,although the period of replication is somewhat prolonged.
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